Appendix C

Appendix C: Comparative Lethality of Selected Toxins

And Chemical Agents in Laboratory Mice

AGENT	LD₅₀(m g/kg)	MOLECULAR WEIGHT	SOURCE
Botulinum toxin	0.001	150,000	Bacterium
Shiga toxin	0.002	55,000	Bacterium
Tetanus toxin	0.002	150,000	Bacterium
Abrin	0.04	65,000	Plant (Rosary Pea)
Diphtheria toxin	0.10	62,000	Bacterium
Maitotoxin	0.10	3,400	Marine Dinoflagellate
Palytoxin	0.15	2,700	Marine Soft Coral
Ciguatoxin	0.40	1,000	Marine Dinoflagellate
Textilotoxin	0.60	80,000	Elapid Snake
C. perfringens toxins	0.1 - 5.0	35-40,000	Bacterium
Batrachotoxin	2.0	539	Arrow-Poison Frog
Ricin	3.0	64,000	Plant (Castor Bean)
alpha-Conotoxin	5.0	1,500	Cone Snail
Taipoxin	5.0	46,000	Elapid Snake
Tetrodotoxin	8.0	319	Puffer Fish
alpha-Tityustoxin	9.0	8,000	Scorpion
Saxitoxin	10.0 (Inhal 2.0)	299	Marine Dinoflagellate
VX	15.0	267	Chemical Agent
SEB (Rhesus/Aerosol)	27.0 (ED₅₀~pg)	28,494	Bacterium
Anatoxin-A(s)	50.0	500	Blue-Green Algae
Microcystin	50.0	994	Blue-Green Algae
Soman (GD)	64.0	182	Chemical Agent
Sarin (GB)	100.0	140	Chemical Agent
Aconitine	100.0	647	Plant (Monkshood)
T-2 Toxin	1,210.0	466	Fungal Mycotoxin

Nuclear

Biological

Chemical

Chemical

North Anna Power Station

Surry Power Station

UVA Nuclear Reactor Facility
Decommissioned in 1998

FEMA Fact Sheet:
Nuclear Power Plant Emergency

Introduction

Medical Management

History of Biological Warfare and Current Threat

Medical Aspects of the Biological Threat

Bacterial Agents
Anthrax
   Brucellosis
   Cholera
   Glanders
   Plague
   Tularemia
   Q Fever

Viruses
    Smallpox
    Venezuelan Equine Encephalitis
    Viral Hemorrhagic Fevers

Biological Toxins
Botulinum
   Staphylococcal Enterotoxin B
   Ricin
   T-2 Mycotoxins

Personal Protection

Decontamination

Appendix A:
Glossary of Medical Terms

Appendix B:
Patient and Precaution Levels

Appendix C:
Comparative Lethality: Toxins/Chemicals

Appendix D:
Aerosol Toxicity: Toxins

Appendix E:
Differential Diagnosis: Toxins/Nerve Agent

Appendix F:
Specimens for Lab Diagnosis

Appendix G:
BW Agents: Lab Identification

Appendix H:
BW Agents: Characteristics

Appendix I:
BW Agents: Vaccines, Therapeutics and Prophylactics

Appendix J:
Medical Sample Collection for Biological Threat Agents

Introduction

Nerve Agents

Mustard Agents

Hydrogen Cyanide

Psychotomimetic Agents

Potential CW Agents